Jacob Gutierrez bio photo

Jacob Gutierrez

Motivated Computational Biologist with experience in Petabase-scale Computational Virology, Single Cell Genomics, and Clinical Informatics

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PhD Candidate in Cancer Biology at Gerstner Sloan Kettering.

Background and Interests:

Currently working in the Lareau Lab at Memorial Sloan Kettering Cancer Center, analyzing petabyte-scale biorepository and public sequencing datasets on cloud compute infrastructure for viral sequence detection and discovery, to derive insight into the genetic architecture of viral persistence at the population scale. Additionally analyze in-house single cell datasets generated from novel technology development projects, and provide broad bioinformatics support spanning experimental design, data processing, and interpretation for genomics and virology projects both in house and with collaborators.

  • Petabyte-scale sequence analysis (WGS/WXS)
  • Genome wide variant association testing
  • Viral detection, discovery, and de novo assembly
  • sc-RNA/ATAC-seq, mtscATAC-seq, scRNA+ATAC multiome
  • Protein structure prediction and comparison
  • etc.

Previously worked in the Satpathy Lab at Stanford University leveraging single cell datasets to derive novel insights in normal health and disease.

  • mtscATAC-seq and mitochondrial lineage tracing
  • ASAP-seq, CITE-seq, and single cell multi-omic profiling
  • NanoString CosMX Spatial Transcriptomics

Previously worked in the Maslen Lab at Oregon Health & Science University studying Genetically Triggered Aortic Aneurysms.

  • NGS sequencing including Whole Exome sequencing, Targeted and Whole Genome Bisulfite Sequencing
  • Genetically Triggered Aortopathy in Turner Syndrome
  • DNA methylation analysis and visualization

Current Projects:

My current research interests include:

1) Host control and regulation of human anellovirus persistence.

2) Resolving human neuronal herpesvirus reactivation via petabase-scale association studies.

Previous research interests:

1) Longitudinal mitochondrial lineage tracing of blood in healthy donors.

2) Latent human herpesvirus 6 reactivation in chimeric antigen receptor T cells.

3) Thesis Project explores epigenetic alterations in DNA methylation related to Bicuspid Aortic Valve in Turner Syndrome.